Multiplexed High-Density Bio-Agent Arrays
The ability to determine the presence and identity of a biological warfare agent dictates the initial response and decontamination efforts that will be required to mitigate the release. The multiplexed, highdensity array was developed to be a universal sensing platform for BW pathogens. The platform is based on an array of microsensors displayed on the end of an optical imaging fiber. Each microsensor possesses chemistry and/or biochemistry enabling it to perform an analysis for different species’ DNA sequences and can also be adapted to proteins using immunoassays. Replicate microsensors for each analysis provide low false positive and false negative results. The technology has been demonstrated to perform these analyses using specific molecular recognition, biosensing, immunoassays, and DNA microarray chemistries. Multiplexing of over 1500 different selectivities for DNA sequences has been demonstrated, as well as multiplexing of immunoassays and small molecules. This technology has been licensed from Tufts University to Illumina, Inc., which is developing next generation genotyping arrays. For additional information please fill out the Contact Information Form.